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[5] [6] Early-phase clinical trials including a Phase 2 trial published in the New England Journal of Medicine (2023) have reported significant reductions in body weight and improvements in metabolic markers, though this evidence remains preliminary and is not sufficient to establish a clinical dosing or reconstitution standard

Consult Your Doctor Persistent or severe headaches after a B12 shot should be discussed with your healthcare provider: Your doctor can determine if dosage adjustments or different injection methods are needed